Search results for "ISM [Radio continuum]"

A synthetic hexapeptide (Argireline) with antiwrinkle activity

2008

Botulinum neurotoxins (BoNTs) represent a revolution in cosmetic science because of their remarkable and long-lasting antiwrinkle activity. However, their high neurotoxicity seriously limits their use. Thus, there is a need to design and validate non-toxic molecules that mimic the action of BoNTs. The hexapeptide Ac-EEMQRR-NH2 (coined Argireline) was identified as a result of a rational design programme. Noteworthy, skin topography analysis of an oil/water (O/W) emulsion containing 10% of the hexapeptide on healthy women volunteers reduced wrinkle depth up to 30% upon 30 days treatment. Analysis of the mechanism of action showed that Argireline significantly inhibited neurotransmitter relea…

Sequiterpene-related compounds as endocrine disrupters in Oncopeltus fasciatus, and potential reduced glutathione synthesis modifiers

1999

Sesquiterpene lactones have been found to exhibit effects on insect growth and development. In this study, the bioactivity of natural lactones extracted from Centaurea mariolensis and some structurally related synthetic derivatives has been investigated. Assays have also been carried out in order to determine the potential of these lactones as modifiers of reduced glutathione (GSH) synthesis.

Bioactivation of the Fungal Phytotoxin 2,5-Anhydro-D-glucitol by Glycolytic Enzymesisan Essential Component of itsMechanism of Action

2002

An isolate of Fusarium solani, NRRL 18883, produces the natural phytotoxin 2,5-anhydro-ᴅ-glucitol (AhG). This fungal metabolite inhibited the growth of roots (I50 of 1.6 mᴍ), butit did nothave any in vitro inhibitory activity. The mechanism of action of AhG requires enzymatic phosphorylation by plant glycolytic kinases to yield AhG-1,6-bisphosphate (AhG-1,6- bisP), an inhibitor of Fru-1,6-bisP aldolase. AhG-1,6-bisP had an I50 value of 570 μᴍ on aldolase activity, and it competed with Fru-1,6-bisP for the catalytic site on the enzyme, with a Ki value of 103 μᴍ. The hydroxyl group on the anomeric carbon of Fru-1,6-bisP is required for the formation of an essential covalent bond to ζ amino fu…

Plant-growth-regulating phosphono peptides

1990

Phosphono peptides exhibited plant‐growth‐regulating activity when tested on Lepidium sativum and Cucumis sativus. The studies have provided evidence that the mechanism of action of these compounds may involve the uptake of the phosphono peptides into the plant, intracellular hydrolysis of the peptide bond and release of the P‐terminal aminoalkylphosphonic acid. This acid or its metabolite is then probably responsible for the observed physiological effect.

Mode of action of herbicidal derivatives of aminomethylenebisphosphonic acid. Part II. Reversal of herbicidal action by aromatic amino acids

1997

The herbicidal action of N-pyridylaminomethylenebisphosphonic acids is accompanied by an impairment of anthocyanin biosynthesis. This suggests that they might act as inhibitors of some steps in aromatic amino acid biosynthesis. Herbicidal effects were reversed by aromatic amino acids using both bacterial and plant models, a finding that strongly supports this hypothesis. Structural features of these compounds suggest the sixth enzyme in the shikimate pathway 5-enol-pyruvoylshikimate-3-phosphate (EPSP) synthase as a possible target, since a strong structural similarity exists between aminomethylenebisphosphonic acid and an inhibitor of EPSP synthase, the herbicide glyphosate. This is, howeve…

The Mechanism of Action of Carbonic Anhydrase

1990

A survey of the structure-function relationship in the enzyme carbonic anhydrase is presented. The coordination number around the metal ion in derivatives inhibited with some anions is stressed as well as the role of the cavity in determining the coordination number. Inferences on the enzyme-substrate interactions are presented.

Mechanisms of photosensitization by drugs: Involvement of tyrosines in the photomodification of proteins mediated by tiaprofenic acid in vitro

1997

The photosensitizing potential of drugs must be related to their photoreactivity towards the target biomolecules. In this context, a representative photosensitizing drug (tiaprofenic acid) was co-irradiated with a model protein, bovine serum albumin (BSA). This led to a significant degree of protein crosslinking and to the formation of trace amounts of drug-BSA photoadducts. Amino acid analysis of the hydrolysed (HC1) protein showed that His and Tyr undergo a dramatic decrease (approx. 90%) as a consequence of drug-mediated photodynamic processes. When the drug was irradiated in the presence of the pure amino acids, extensive phototransformation of the latter was observed. Other photosensit…

Chrzest i Eucharystia w nauce Soboru Trydenckiego i współczesnego Katechizmu Kościoła Katolickiego

2017

Artykuł prezentuje problematykę chrztu i Eucharystii przedstawioną w nauce Soboru Trydenckiego i aktualnego Katechizmu Kościoła Katolickiego. Za sprawą reformatorów nauka o chrzcie, a zwłaszcza o ofiarniczym charakterze Eucharystii i realnej obecności Chrystusa pod konsekrowanymi postaciami stała się przedmiotem poważnych kontrowersji, które doprowadziły do tego, że biskupi katoliccy potrafi odnaleźć w Trydencie odwagę, aby dochować wierności Tradycji apostolskiej, co wyrazili w odpowiednich dekretach. Po upływie ponad czterech wieków w Kościele katolickim zrodziła się potrzeba wyraźnych wskazań dotyczących rozumienia prawd wiary. Wielu wiernych miało trudności z jasnym wyrażeniem prawd gło…

Organizacja obchodów 1025 rocznicy Chrztu Rusi Kijowskiej jako przykład szczególnych relacji Państwo-Kościół na Ukrainie

2018

Social Sustainability on Competitiveness in the Tourism Industry: Toward New Approach?

2020

The achievements made over the years of policies seeking to stimulate tourism demand have led to a great increase in the number of tourists arriving in many destinations. Some destinations have begun to suffer problems derived from the success of policies focused solely on increasing the number of arrivals. The objective of this work is to analyze the role of social sustainability in the analysis of tourism competitiveness. Methodologically, this study has been developed from the analysis of papers published in journals indexed in the Journal Citations Reports and Scopus. This has been complemented with information extracted from a number of well-known studies regarding tourism competitiven…